Cytotoxic Activity of Compounds from Vietnamese Goniothalamus elegans Ast

Tropical Journal of Natural Product Research (TJNPR) - Q3

Nguyễn Tấn Khanh-Scientific Management Department, Dong A University, 33 Xo Viet Nghe Tinh, Hai Chau district, Da Nang city 550000, Vietnam

Phạm Trần Vĩnh Phú - Faculty of Medicine, Dong A University, 33 Xo Viet Nghe Tinh, Hai Chau, Danang 550000, Vietnam

Abstract

Goniothalamus elegans Ast is a plant commonly used in traditional medicine for the treatment of heart disease and diarrhea. Although there has been one published study on its chemical composition, limited research has been conducted on its bioactivity. In this study, the aerial part of G. elegans was extracted using the soaking method and further subjected to column chromatography for isolation. The isolated compounds were then evaluated for cytotoxicity using SRB staining. From the aerial part of G. elegans, four compounds were successfully isolated and identified as (23R)-21,23-epoxy-5a-cycloart-24-en-3ß-ol (1), stigmasterol (2), aristolactam BII (3), and piperolactam C (4). Among these compounds, aristolactam BII and piperolactam C exhibited moderate cytotoxicity against SW-489, AGS, LU-1, and HepG2 cell lines, with IC50 values ranging from 55.55 to 96.21 µg/mL. This study reveals that the phytochemical composition of G. elegans and demonstrates its potential cytotoxic activity, indicating promising avenues for further exploration in future research endeavors. 

DOI; http://www.doi.org/10.26538/tjnpr/v7i7.31